We where not using any features on the 6500 that where not available on the 7010. Basically our two 6500 do L3 and L2 with no special modules etc. installed. We discussed this at length with or Cisco Sales Engineer because we where debating between a 6509-E,6513-E or the 7010. We also debated about layering in new 6500s with a Nexus 5ks as a distribution switch in the Data Center with the 6500 staying as the core. At some point one of our senior network guys sat down with the Cisco SE and went over or current 6500 config to make sure all the features we currently used are supported in the Nexus Chassis. After all was said and done the Nexus was about 20% more expensive than the 6500 however it offered a incredible amount of bandwidth potential and growth potential. The 6500 has some good modules however we have never used any of them and have no plans to.
The current chassis's we are replacing where first installed in 1999. The Sup engines and cards have been updated over time. We have very much gotten or money's worth out of the 6500. Management also felt that since the Nexus is a lot newer platform than the 6500 the Nexus down the road will have more growth potential than the 6500 which is literally from the last century. Not saying I completely agree with their reasoning. Personally I would have liked to see the Nexus 5k at the Distribution layer in the DC and a newer 6500-E remain at the Core. However this combination pushed up the price beyond just doing the Nexus 7k as both Core and Distribution. So during budgets last year the decision was made to go Nexus 7k.
Being you are talking data center then Nexus is probably the better match. However, saying the 6500 is from the last century so the Nexus will have better growth potential is totally wrong. Both will be current and improving lineups for a long time. Cisco is not decommissioning the 6500 chassis at all, but will continue to improve it as well. The E series is majorly different from the original 6500.
With all the non-E 6500's going out of support NOW you will see many thinking going to Nexus the smart move. In the data center it can be, outside of it usually a bad call. There are feature sets for the 6500 that will never be offered in the Nexus lineup that are critical for large businesses to get connectivity out to their end users.
Also I don't agree with mixing Nexus/non-Nexus unless budget dictates that as a stepping stone.
In the data center: Nexus 7k->5k->2k etc.
In the business: Cisco 6500->3750->2960 etc
Also add in the fact that Nexus is a very different animal as far as configuration. Re-tooling your people/staff to support the new platform is another heavy cost.
We are the number 2 Cisco partner, we sell both platforms everyday so I have no reservations to recommend either, but neither is a one-size fits all platform.