Any issues with power?
Not really.
Reliability of the device itself is a big unknown. By that I mean, they will all fail, so, mitigate that with using multiple devices, and use backup software that actually does verification.
I wouldn't contend that. But one could assume that 2.5" drives are made to last as long as a laptop, or intended to, even if they don't. And if power is cleaner coming from my Seasonic "Titanium" PSU, it would offer less risk or chances of failure than more.
This just seems to be an only partially-charted territory regarding these drives, while these drives have been around over a considerable amount of time through many generations of laptops. I think they are used in desktop "AIO" computers in banks. I'm sure that Bank of America doesn't count on 2.5" drive reliability even if their AIOs use them, but I've seen those machines with the small HDDs in many business applications.
I might still have some doubts, but I just returned from blowing the kruft out of my brother's system upstairs. It is equipped with a 3-year-old 500 GB WD Blue 2.5", and it's chugging along just fine.
Bro doesn't know he's a guinea pig, but his system is backed up nightly to the server -- so I'll never need to tell him regardless of whatever happens. Or -- I'll ask him to file a FISA request. And I deny that his phone is tapped.