From what I've seen the leaks are only an issue on the AWD models. If AWD is a must then that may be a deal breaker. I haven't seen any huge reliability concerns with the RX330's, its just when they break it will cost you. For example a power window switch isn't just a power window switch, its an entire module that sets you back $500-600.
In looking up the switch that you reference, I've found some sets on ebay for under $100 and power window motors on rockauto for $140 or so. While definitely more than I spent for similar items on a Jeep Grand Cherokee, it isn't too terrible. And most of the nickel/dime issues I'll fix myself. It's the major stuff that I'll likely have someone else do.
But at this point, the Edge AWD was close to my #1 option, but having read someone suggest that the PTU blew up, sent metal shavings into the transmission, and the total repair bill was close to $6-7k, I can deal with all of the switches dying on the Lexus and still have $5k left over.
And who knows, the person suggesting that issue with the Edge may have been exaggerating, or using a very costly service center, but there were plenty suggesting the PTU problems set them back $1500 or more, and several suggested dealing with it more than once.
Honestly, for the past several days, I have been trying to sell myself still on the Edge, but if I were to pay 1500 more than once for the same repair, I'd likely ending up selling the car at a loss.
I've also tried to think about getting a FWD Edge, but one site suggest that the FWD edges also experience the problem. Not seeing how this makes sense as I had assumed the PTU was in relation to the AWD system, but maybe those folks were having issues with the transmission sensors that was a part of the other issue.
Nonetheless, those two things just seem to be a bit too common. I have no problem if they chew up wheel bearings or something simple, but one of forum suggested taking a LOT of stuff apart just to fix the PTU problems. At that point, I'm giving up on it. I really liked the car, but I just cannot risk seeing that problem at 1500 when it seems to be fairly common.
At this point, the Lexus makes the most sense. Many seem to think they're terribly expensive to fix. And while it isn't a Dodge, Ford, or Chevy, it also isn't a BMW or Mercedes. I'd put it closer to Dodge, Ford, or Chevy than I would BMW or Mercedes. Most of the mechanical stuff is Toyota based. The electrical components are likely more Lexus specific, but I can deal with an occasional problem at a slight premium over what I give for the parts I need for my Chevy truck or whatever. As long as the motor and transmission are solid, I can get through the rest of it I think.