For me...
Perhaps Borderlands 2, Far Cry 3 and maybe Darksiders 2, that's about it. I'm also interested by the Tomb Raider reboot, but I don't have a 360 nor a PS3 myself. If my cousin buys it for his 360 I might play it a bit, although if it was released for the PC I think I'd buy it, but I would have to buy a proper controller. I used to be a fan of Tomb Raider back in the days... meh, I guess I can admit that I've played them all so far, but I never completed the third one (saw the ending on YouTube).
I know that as far as Borderlands 2 and Far Cry 3 goes I'm "interested" just because they happen to be first-person-shooters basically, but really, their respective settings or "story" is far from what I'm totally looking for. I've never been interested by Crysis 2 enough to play it past the first map on my cousin's 360, I don't think I'll bother with the third, although I did liked the first and Warhead as well. I still run my games on my GTX285 anyway, its aging a lot and even the first Crysis can't run smoothly at maximum settings, much less Crysis 2 with HQ textures (perhaps even without them). It's time I upgrade my GPU heh.
For now I'm busy enough with D3, two F2P MMOs I play occasionally, along with my game in progress in Witcher (the first, still haven't touched the second one even though I bought it like two months ago) and a few Indie games I've bought recently.