It should... I would be pissed if it didn't. I did it with the hoses curved almost to the front glass, with the water block in the estimated position, and the video cards will be to the left of the CPU in this config. (IO plate up)will that cpu block reach over your gpu?
Well thats a pain in the arse... Can't you just run distilled water and a silver coil ?8:2 ratio would be what i consider optimal, so your good on the coolant mix.
I would not freak out when you do maintance and you notice jelly like deposits in your cpu block.
Its just the glycol clumping up.
You will need to flush your coolant ever 6-9 months tho to minimize the clump up and possible staining.
With no hardware in the case, it took me 2 hours to fill that and clean up the mess (you can't fill very fast). Now I will have to figure out how to do this easily.lol you still would need to flush at least yearly.
It is a lot easier because your not premixing anything, and its just straight distilled.
I do mine bi yearly, which is why its important to add a good and working drain in your system.
Think of it like an oil change, you don't want old coolant in your system too long, it keeps your parts clean, and gives you less maintenance in the long run.
I fill up the res about 3/4 with a funnel or squeeze bottle, turn on my PSU (only pump hooked up) and flip it off when the water level is almost gone, repeat until water no longer goes down. Draining, I have a ball valve at the bottom of my loop. I hook up an appropriate length of soft tubing, remove the stop plug from my res and open the valve.With no hardware in the case, it took me 2 hours to fill that and clean up the mess (you can't fill very fast). Now I will have to figure out how to do this easily.