I went through and setup Unraid with the i5-12400 and ASUS Z690 Prime D4 over the weekend. Overall... it wasn't too bad, but there were definitely a few Unraid-related hiccups that I ran into. Fortunately, I was able to quickly find resources to help me fix the problems since I am a bit of a 'Nix Newbie.
Unsurprisingly, I ran into an issue with the drivers for the CPU's integrated graphics. What I saw at first was that the screen hooked up to my server just displayed a flashing cursor at the top left instead of a login screen. I was able to use any remote, web-based connection (like normal) to access it. From what I saw, I needed to either manually enable the iGPU's drivers or use the Intel GPU TOP plug-in to do it for me. I went with the latter as it also enabled me to use the GPU Statistics plug-in. However, a post on the forums noted that I would also have to update an i985 config file, which I believe tells Unraid to not load the driver, and allows the plug-in to load the driver?
I also upgraded to 6.10 RC2 from 6.09. I don't think that was necessarily required, but given that I'm using new hardware, I figured upgrading back-end components to the latest would probably help with compatibility.
In regard to the ASUS Z690 Prime D4, this is going to sound kind of negative, but I think this board really represents how I've seen people complain that Z690 boards seem more expensive than prior generations. I have the non-WiFi version, which costs about $210, but when working with the board... it felt more like a $160 board from earlier generations. With the cheap looking I/O shield and how there are mounting points for a bottom M.2 heatsink, it definitely seems like choices were made to cut features from this board to reduce its cost. As a personal preference, I usually prefer motherboards that reach the third set of ATX stand-offs. This board goes up close to them, but does not actually reach nor have mounting holes for them.
As for the build itself, I didn't really have any problems. Although, there is one thing that I didn't consider in regard to the expansion slots. I'm currently using an older LSI RAID card, which is only PCI-E 2.0 x8, but while the Z690 Prime D4 has four x16 slots, only the first one is actually x16; the rest are all x4. So, I believe this means the card is limited to PCI-E 2.0 x4 speeds? Digging a bit deeper, the SFP+ card is only an x4 card, so I should probably move it to the other slot and let the 8x RAID card get a bit more bandwidth.