From my research (I could be wrong) - some of those monitors don't have a scalar ability to properly display videos or images from some source GPUs because they are only pass through scalars. It may cause communication problems from the monitors' board to the GPU's video outputs. It may be one reason why they have a list of cards or device sources of what may or may not work properly.
Which could also explain they may have issues with particular GPUs in multi-monitor configurations.
Try one of these possible solutions:
1) try switching your 4K monitor to an HDMI output to see what happens.
2) Take out out the GPU in the PCI Express Slot #1 and only use the GPU in PCI Express Slot #2. Next connect everything into the GPU that is only using the PCI Express Slot #2
See if any one of those two makes the flickering go away.
I just want to clarify that some monitor vendors do ship monitors with issues - and that in the past AMD did release minor driver updates to fix those monitors. But those fixes were mainly for monitors that were not VESA compliant - may be those fixes did not carry over to the new drivers.
From looking at all those videos with monitor issues in this thread - I have seen them before. And we resolved every one of them by swapping out monitor parts or updating the monitor firmware.
I don't think this is going to assist him. Also, HDMI uses the same output clocks as DVID, I don't think he can hook up 2 DVID and one HDMI at the same time, and I believe in a previous post he tried all kinds of different output options as well.
I have a similar problem with different monitors. Also no issues on 15.1, issues with 15.7 onward.
2x FHD2401 1920x1200 DVI
1x HP ZR24w 1920x1200 DP
After approximately 1 to 2 hours Ill get tearing and flickering that goes across all 3 monitors in eyefinity mode and have to turn eyefinity off and back on for temporary relief.
Also do not have options for bezel compensation on 15.6 onward.
I have been using the monitors for years without issue.
I have the problem in windows 7 and windows 10. The bad thing is in W10, 15.1 is not an available driver for me to use which is really the best driver for my configuration.
My 2c I believe they changed something in 15.7, maybe related to W10 or freesync support that affected systems not even on that configuration.
AMD fixes it soon or I switch when the new cards arrive this year.