Just an update on my system, specs as follows:
Ryzen 3600 set to Auto OC
Cooler Master Hyper 212 LED tower cooler
Arctic Cooling MX-4 thermal paste
ASRock B450M Pro4
XFX reference 5700, stock
2x8GB 3200CL16 (currently at 3400CL20, anything tighter on timings produces mem faults) Trident Z RGB
~3550-3600 in CB20
Running F@H beta on Navi with 1 CPU thread
Running WCG and Rosetta@Home on 11 threads
CPU max temp 75-76C, max clocl 3.968 GHz
GPU peak hot spot 84C, peak clock 1.465 GHz
Has been stable for several days, just started F@H full-bore today, but all is going well. My main upgrade consideration is faster RAM.
Even better, I can still work in office and electronic medical records and watch YouTube videos and so on without any perceptible slow-down in responsiveness.
Overall keeps my typically chilly office a little warmer and keeps my heart a little warmer on the off-chance my computer might help find some good treatments for cancer.