Just one major question: why the low profile cooler? While that cooler is very good, you're compromising on both cooling capability and noise simply due to the fact that it's rather tiny. The Define R4 has plenty of space for big air coolers. Pretty much any tower cooler would outperform that when you look at noise and temps together.
Also, don't get the R4 if you're ever considering water cooling. I'm getting rid of mine mostly for that reason (although the desire for a smaller PC also plays into it). It also shows its age in a number of ways - front fan mounts are less than ideal for vibration dampening, cable routing is so-so, top vents are an eyesore if used. Other than that it's a great case.