Dunno about downtown (in NYC for many, a 10-15 block radius is practically their own "city" within the city), but where I work in the UES, there's MAJOR horrendous blasting from the construction of the 2nd Ave subway, sometimes 4 times within a span of a few hrs. Shakes and rattles the store, feels like a 5-7 sec. earthquakes sometimes.
Whatever you do, drive only if you have no other choice. Driving from Queens over the 59st. bridge (NOT gonna call it the Ed Koch bridge, fuck it) and into a den of endless ruts, construction plates, 2 lanes blocked by trucks, diversions, and sanitation trucks will give you nightmares. Then the issue of municipal parking which just happened to have doubled its rates over 2 months ago- $3 for 1 hr of parking, just shoot me. Even if you live in Manhattan, it's still better to take public transportation or the taxi sometimes.
For me, even though I'm quite busy with my job with scores of loyal customers, I feel beat down to no end. If I can move out, I'll try to find someplace with 1) fast internet 2) good healthcare 3) near a national park or big body of water.
The only upside to working in the city are the women- unbelievably fit, fashionable beauties who have no hesitation going out at all hours in their tightest yoga pants for a pilates or manicure.