A backup application called Retrospect is by far the most popular backup tool used in corporate environments, so you can look into that. I think that would suit you nicely as it has a ton of useful features such as automation, etc, but the software isn't free. I think the app goes by a different name now, but you can try googling for it.
Edit: I think it goes by the name of BackUp MyPC now, but I could be wrong.