Doesn't matter in the slightest.
These questions have nothing to do with any point I've made.
They matter immensely. If we are going to talk about mutation rates, we have to understand the how and why they are calculated. One cannot just throw numbers out, ignore the denominators of what they represent like you have. So if we are going to talk about mutation rates, I have to know what your knowledge base of them are, especially if you are going to post papers on here about them. So:
1) Did you read that paper?
2) If so, how did they determine the 1x 10^-9 value? How is their calculation different from the other paper I previously mentioned and their mutation rate per nucleotide site?
When did I say that? Why are you framing every statement I make like this? Does dishonesty make you feel good?
They don't matter.
Take a hike.
You can ask until a 3 point mutation occurs in your brain and you finally understand my mathematics. Did you notice that I said it was a candidate? Why do you dishonestly rephrase my statements into declarative assertions? You're either insane or stupid. I'll assume you're insane and that you can't help it.
The only dishonest person is you. You've been caught three times making statements that are completely false. If you want someone like Hillary Clinton prosecuted for making false statements, why aren't you owning up to them?
But the fact is, you mentioned the Citric Acid Cycle as a "candidate." So please explain to everyone reading this thread why is it a candidate example of a cell requiring three mutations? Why did you bring it up at all? You spoke about it, there must be a reason. Or are you just making things up in a vain attempt to sound educated? Its ok to admit that you are only making things up, people already recognize your strawman argument.
But if you don't want to use the Citric Acid Cycle as your example of situations in which three mutations are required in a cell, what is your favorite example? Because, if you don't have any examples, your posting about "cells having three mutations" is nothing but a bunch of hot air, purposely made to distort reality.
A completely irrelevant amount. You still don't understand my point yet you act like you do.
Ah, but it is completely relevant, especially once you do the math. How many mutations will be generated in a week? 10 years? 1,000 years? I'm using the mutation rate from the paper you cited. So do the math, how many mutations are generated given the genome size and log growth parameters of E coli?
I didn't say they didn't exist, I said I didn't have any examples.
Caught three times in only a few posts.
So when are you going to finally talk about all these novel genes that you claim don't exist?
Long M, VanKuren NW, Chen S, Vibranovski MD. New gene evolution: little did we know. Annu Rev Genet. 2013;47:307-33.
Called me insane [x]. Called me an idiot [x]. Unfortunately for you, your posting demonstrate your dishonesty and vain attempts to sound educated on the subject. If you really meant to discuss the Citric Acid Cycle, why did you bring it up?
buckshot24 said:
As soon as you accurately explain my mathematics then we can discuss Krebs. Until then I see no reason to waste our time.
We cannot discuss your mathematics unless I know that you understand how the 1 x10^-9 value was calculated in the first place. Why is it different from the other paper I previously posted? These discussions cannot occur unless I know you actually understand how that number was calculated.
Did you read that paper?