ESDF. I see no reason to use WASD, my pinky can hit the control key and my thumb the alt key just fine. I can reach all the keys on the left side of my split keyboard, and ESDF feels natural because it's where your hand is to type anyway. A 10 year old or a midget must have come up with WASD, not sure why it ever caught on.
Inverted mouse too, oldschool style