Over time, seperation can occur. Putting the tube into a fridge would help slow down this process; however, seperation is inevitable (over a horribly long period of time). Arctic Silver recommends storing the tube in an upright position so that if seperation does occur..... the more usable stuff would be near the tip. I have a large clear tube of AS5........it has been about a year now, and I have noticed a small colour difference when comparing both ends of the tube. If the tube is small, and you are concerned with shelf life, I simply recommend buying a new tube since the price is rather low. Personally, I would just use the paste without worrying too much.