I'm pretty happy w/ mine.
a8n-e
winchester 3200+ PIB, OC'd to 2.3ghz
corsair value select, 1gb, running at 5:6 (didn't get too aggressive with this)
msi 6600gt video
seagate 7200.8 sata drive
No problems building at all. System has been pretty darn stable. I've had it for around 6 weeks now.
The motherboard fan is pretty annoying. I bought a $15 zalman fanmate, detached the existing fan from it's power source, and use the 80mm fan that came w/ the fanmate to cool the motherboard chipset. After several hours of gaming, the motherboard doesn't get hotter than around 35c. Asus is supposedly offering replacement chipset fans to replace the existing screamer.
I enabled the asus qfan feature. This controls the speed of the cpu fan, bringing it down from the stock 3000rpm, to around 1200rpm. It supposedly speeds up the fan after the temp reaches a configurable threshhold. The threshhold can be as low as 50c, if I remember correctly. I've never gotten the proc temp above 50c though, even after a few hours of prime95.