BTX is a fresh design. The entire box has a design philosophy focused on efficiency, aero and electric.
The CPU gets a blast of fresh air, with the chips and vid card right behind it. BTX specs airflow under the mobo as well. The cooler, that so many complain about, is much smaller than some of the monsters we already install. Besides, it's inside the box, so what's the problem?
Board layout is vastly simplfied, and more standardized. We can expect less awkward plug locations and angles, and legacy crap is a much needed step closer to death. The mobo isn't upside-down, like some pretenders today. The design puts the memory parallel to airflow. With current CPU sockets, this won't work, due to the mem controller traces. So, they flip the whole thing around. Anyway, shouldn't the vid cooler point up, and face open air? BTX does it. When layed flat, BTX allows for some very small systems.
The new form factor also makes things more efficient for mobo manufacturers. They design a board, and simply add or subtract from it to make different sizes. A full-size powerhouse will also be available in micro form, being identical except for the number of PCIE / PCI slots. A family of boards will share BIOS, drivers, everything. This is very budget-friendly for them, and easy on users. BTX will have a huge impact on business machines.
Today's new power supplies will be 100% OK, obviously future BTX spec changes will raise the bar.
In a couple years, you'll be able to use a computer that has a high performance CPU(s) and vid card(s), powered by a 90% efficient PS, and be air cooled by a single, quiet fan. Slightly better electrics, and BTX, will make this happen.