Drew Bledsoe "...much he had to get a transfusion".
("Wrong, Drew Bledsoe has no nickname!!!")
Jack "The Assassin" Tatum
Jerome Bettis - "The Bus"
Willie "Stretch" McCovey
Johnny "Disaster" LeMaster
John "The Count" Montefusco
Reggie Jackson - "Mr. October"
All the boxers named Ray who used "Sugar"
Thomas "The Hit Man" Hearnes
"Iron" Mike Tyson (also "Iron" Mike Ditka)
Actually my favorite is one my brother made up for a former San Francisco 49ers defensive back:
Dana "Nowhere Near the Ball" Hall.
It just rolls right off the tongue.
MotionMan