I normally hate all things pasta, but I was in Rome and "when in Rome...", so about 2 blocks off the main drag into the Vatican my dad and I found a hole in the wall restaurant. I went with simple spaghetti and not only was it the best pasta I have ever had, it was the best meal I have ever had.
A distant second was the best cheeseburger I ever had, at the Whistlestop diner in Winslow Arizona. I say distant second because it could have been the hunger that drove me to think this cheeseburger was the end all be all of food.