Worst was reversing the usb pin connectors on the motherboard (back before they got smart and made modular plugs). Plugged my 128mb jump drive in after I got the system up and running, to transfer some programs to it. It gave a little POP! and a thin wisp of smoke came out of the casing of the jump drive. It was fried. I even took it apart, and saw the little black spot on the circuit board where it fried. Sucked too, since those little drives used to be damn expensive!! Luckily, it didn't fry the usb on the motherboard, so I fixed the pin issue and it was okay.
Built a computer once, and installed two optical drives (cd-rom and cd-rw). Set the jumpers on them as I installed them in the case. Turned on the computer, and wondered why the bios screen was taking FOREVER to recognize the drives?? Seems it really confuses the hell out of the motherboard bios when you set both drives on one cable to master!!
The most painful was when I took a tower cover off (back before they had removable side panels), and being in a hurry, just set it next to my desk (where I'd have to walk). Went around the desk to get something, stumbled, and stepped back to catch my balance.....and sliced the back of my calf with the sharp edge of the metal! Still have a nice 1" long scar back there to remind me not to get in a hurry!! :roll: