Fair enough, my physics knowledge is very basic as it is.
I'm planning on running positive pressure in my next build as I have a cat and dealing with dust/cat hair is really annoying. Case will be a Corsair 550D.
you'll thank yourself in the end for running positive pressure even though you have your doubts about whether it'll do a good job of keep dust/fur/hair out of your case. i can understand where you're coming from, as its tough to imagine that an object that isn't air-tight in the first place could possibly maintain either a net positive or net negative pressure. but a net positive pressure inside the case means that the only air coming into the case will be through the intake fans. the air being exhausted from the case will exit through the exhaust fans
and any any seams or weak points in the case that won't hold and air-tight seal. if you were running negative pressure, it would be the exact opposite - the air being exhausted from the case will only exit through the exhaust fans, while air coming into the case would come in through the intake fans
and those non air-tight seams/weak points. since intake fans can be filtered, the only other way for dust to get into the case is through those seams/weak points...and the only way dust will come in though those seams/weak points is if you run a net negative pressure inside the case.
i used to be a skeptic myself until i tried it with one of my rigs. it really is amazing how such a simple concept can keep most (if not all) dust from getting into the case. i'd be interested in knowing how it goes for you, so perhaps you could post up some results after you finish with your next build...i have no idea how soon that will be, but it would be interesting nonetheless.