I dont know why the heck people have a problem with things like calluses... Calluses are good, they show how much of a man you are. (That is off course not to say that a man without calluses is any less of a man) But having scars, calluses, etc, is all a "manly" thing and it's perfectly normal. If a guy tells you your hands are nasty cause you have calluses he's gay. If your girl tells the same thing, lose her. If she loved you she'd love you with calluses, back hair or whatever and she would accept you just the way you are. If she doesnt love you, no amount of skin care will help you, she will still dump you sooner or later.
And off course if you have a problem with calluses just becuase you do, and you just want to get rid of them cause you think it's ugly or nasty, you're gay. (just kidding) Man up and deal with it - rough hands is NOT a bad thing.