A lot of mobile apps are just wrappers for a website, so the obvious answer would be "yes".
The limiting factors are going to be that some things are difficult or, less often, impossible to do with standard Web technologies, and some things may be difficult or impossible to do with reasonable performance. Especially if you don't want to be limited to browsers that support the latest bleeding-edge standards. You can do lots of fancy things with CSS transforms, for example, but browser support is not uniform and performance for some transforms may be problematic.
Without a more precise notion of what you want to do, it's hard to say much.
And of course as a matter of general principle, "fancier" does not mean "better".