I don't know sh!t about domestics, but hondas/acuras use standard eproms.
An eprom burner and some images and you are on your way.
Chipping a stock engine will not do much for you in most cases. After doing other work to the car, being able to adjust fuel maps and timing electronically can really make a big difference to performance numbers.
However, it is a big myth that you can completely change an engine's performance characteristics with a chip and no other upgrades.
Also it is a myth that you will lose your brakes or other such dumb sh!t. Brakes are controlled hydraulically (at least on every car I've worked on... Honda, Acura, Nissan, Toyota, Chevy) and the computer has nothing to do with braking performance, except in the case of ABS systems that most racers end up disabling anyways
If you want to get into modding chips yourself, it's more or less essential to have the assembler/disassembler for the microcontroller powering your car's computer. Otherwise, your going to be stuck doing binary compares between performance chips (assuming you can get your hands on them) to figure out where important things like fuel maps, timing maps, boost stuff, etc. or whatever else you want to change lies. On the average performance honda chip, timing is adavanced a few degrees, the injector timing is modulated to be slightly longer across the board (leading to a richer mixture) and on cars with a Vtec valvetrain, the point where the vtec solenoid engages can be changed to affect engine behavior.
Honestly, I'd stick to other engine, performance and suspension mods and when you run out of things to spend money on, THEN look at computer upgrades. They're generally a waste of money unless you are running boost on an engine not factory boosted, have a built engine, have done just about every bolt on, or changed fuel injectors to a larger set to handle boost/high HP conditions