Cologuard Test...

IGBT

Lifer
Jul 16, 2001
17,958
138
106
I completed a Cologuard cancer screening test and it came back negative but I'm finding out the Cologuard Test has a high false positive / negative history and can be skewed one way or the other depending on diet / hemorrhoid's nutritional supplements and similar. Anybody have experience with Cologuard Tests??
 

allisolm

Elite Member
Administrator
Jan 2, 2001
25,057
4,496
136
I did one and it came back positive. Very scary time until I had a real colonoscopy and it came back as everything AOK. Their false negative is about 8% and false positive is 12% and goes up with age.
 
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IGBT

Lifer
Jul 16, 2001
17,958
138
106
I did one and it came back positive. Very scary time until I had a real colonoscopy and it came back as everything AOK. Their false negative is about 8% and false positive is 12% and goes up with age.
Could be a racket to charge insurance co's for colonoscopy's??
 

Gardener

Senior member
Nov 22, 1999
763
544
136
No negative experience here over the past 9 years. I'm on an HMO plan so they've done the math on cost/efficacy. If you are in the no-family-history of colon cancer category, the annual stool test is as good as a once every 5 year colonoscopy, according to the metrics used by Group Heath of Washington, now Kaiser Permanente.

Although a mix of both tests is probably the wiser course.
 
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Muse

Lifer
Jul 11, 2001
38,328
8,647
136
No negative experience here over the past 9 years. I'm on an HMO plan so they've done the math on cost/efficacy. If you are in the no-family-history of colon cancer category, the annual stool test is as good as a once every 5 year colonoscopy, according to the metrics used by Group Heath of Washington, now Kaiser Permanente.

Although a mix of both tests is probably the wiser course.
My Kaiser doc is tight ass about colon cancer screenings. At one time I think he recommended one stool test a year, but I had to remind him. I had a couple colonoscopies with Kaiser and got my doc to promise me he'd set me up for another in 5 years but when it came time he wouldn't (I've had polyps in the past and my gastro-enterologist said every 5 years.)! I said "you promised!" He said "what am I going to tell them sending a guy your age for a colonoscopy?" I'm thinking of changing doctors! I'm younger than Biden and he just had one.

I see those ads for cologuard and wonder. I brought up the whole subject when I saw him in person for my first physical since the pandemic, some ~4 months ago. He goes "you're more likely to die of a heart condition than cancer." What could I say? I have a list of reasons to change PCP's. He wants me to stick with him, but I'm not sure he's worth it. He's smart but he's stingy with the HMO's resources.
 
Reactions: Ken g6

Gardener

Senior member
Nov 22, 1999
763
544
136
@Muse I recently had a physical because I needed clearance for a minor outpatient procedure. So I chose to see the first person available...a young Physician's Assistant. During the course of his exam he listens to my heart, pays real attention, and notices a heart murmur that no one else has heard since I was diagnosed with it as an infant...60 years ago. So I get an EKG and an ECG. I mention to the EKG tech how impressed I was with the PA, she says, "Oh yeah, he's the best. We send patients to him whenever we have a question."

Your primary is too uptight. I'd try communicating with him by the message portal...sometimes the written message, which is more formal, gets the required attention and forces your PCP to cover his arse. Kaiser is all about jumping through hoops and checking boxes, unless you self-advocate. The next time I go in I will be seeing the new PA if he is still at the local clinic.
 
Reactions: Muse

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
@Muse I recently had a physical because I needed clearance for a minor outpatient procedure. So I chose to see the first person available...a young Physician's Assistant. During the course of his exam he listens to my heart, pays real attention, and notices a heart murmur that no one else has heard since I was diagnosed with it as an infant...60 years ago. So I get an EKG and an ECG. I mention to the EKG tech how impressed I was with the PA, she says, "Oh yeah, he's the best. We send patients to him whenever we have a question."

Your primary is too uptight. I'd try communicating with him by the message portal...sometimes the written message, which is more formal, gets the required attention and forces your PCP to cover his arse. Kaiser is all about jumping through hoops and checking boxes, unless you self-advocate. The next time I go in I will be seeing the new PA if he is still at the local clinic.
A fair bit to unpack here, but suffice it to say, a big problem with American Healthcare is this idea that "more testing" is better.
 
Reactions: Brainonska511

Muse

Lifer
Jul 11, 2001
38,328
8,647
136
@Muse
Your primary is too uptight. I'd try communicating with him by the message portal...sometimes the written message, which is more formal, gets the required attention and forces your PCP to cover his arse. Kaiser is all about jumping through hoops and checking boxes, unless you self-advocate. The next time I go in I will be seeing the new PA if he is still at the local clinic.
He's been my only PCP since I got on with Kaiser Permanente. He right away made a play for me, saying he planned to stay with them and I could look forward to that stability. He came recommended by a couple of women who worked with him who were friends of my sister, so I figured he had to be good. He knows his stuff, is my impression. But I have always figured him for a guy who plays Kaiser's game, won't go out on a limb and buck their standards. But he did break that promise and he's been overly stingy with other stuff too.

Thing is, he's even tougher to deal with by email. He gives the impression that he's super busy and gives the standard response to whatever the malady is and does it super quickly. Doesn't reread his posts for clarity, typos, whatever, just shoots them off. I don't get the sense of his being personal in those. He goes much more for cultivating the idea that he's your friend when you see him in person. He's all smiles, jokes, handshakes (he insisted in shaking my hand without putting gloves on when I saw him a few months ago, covid be damned!).

I met a guy a few years ago who goes to the same Kaiser facility I do who told me he's super high on his PCP there and recommends I hook up with her. I've been thinking of doing that ever since. I think a woman's a better idea than a man in general. A woman who scanned me at Kaiser told me, it's as easy as a mouse click. I suppose something may push me over that edge.
 

Leymenaide

Senior member
Feb 16, 2010
749
364
136
I did one and it came back positive. Very scary time until I had a real colonoscopy and it came back as everything AOK. Their false negative is about 8% and false positive is 12% and goes up with age.
I had the same experience last fall
 

Muse

Lifer
Jul 11, 2001
38,328
8,647
136
I had the same experience last fall
So, colonoscopy is best. They actually go in there and look. I had IIRC at least 2 sigmoidoscopies before I had a colonoscopy. That's the same except that they don't go all the way up into the small intestine, they go in less far. If they find something then, I believe, they figure next time do a colonoscopy. I had a couple polyps at least one time.
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
I did one and it came back positive. Very scary time until I had a real colonoscopy and it came back as everything AOK. Their false negative is about 8% and false positive is 12% and goes up with age.

Just for comparative purposes, a colonoscopy has, roughly, a 5% false negative rate so about 2-3% lower than Cologuard (not dramatic, but not 0).

So, colonoscopy is best. They actually go in there and look. I had IIRC at least 2 sigmoidoscopies before I had a colonoscopy. That's the same except that they don't go all the way up into the small intestine, they go in less far. If they find something then, I believe, they figure next time do a colonoscopy. I had a couple polyps at least one time.

Colonoscopy is really not much better than Cologuard for detecting colon cancer, however, it is dramatically better at detecting pre-cancerous lesions (adenomatous polyps). If a patient is willing to have a colonoscopy done, I would always recommend it over an alterative for screening, but Cologuard is a really good non-invasive CRC screening alternative.
 
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Spacehead

Lifer
Jun 2, 2002
13,067
9,858
136
I a positive Cologuard test once so had to do the colonoscopy anyway. I was told once i had the colonoscopy i coudn't do a Cologuard test again. Anyone know if that's true?
No a big deal really as it wasn't as bad as some people make it out to be.
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
I a positive Cologuard test once so had to do the colonoscopy anyway. I was told once i had the colonoscopy i coudn't do a Cologuard test again. Anyone know if that's true?
No a big deal really as it wasn't as bad as some people make it out to be.
It's a nuanced answer, but short version is the "value" of Cologuard falls dramatically after a positive result.

"Colonoscopy only" is the screening recommendation thereafter, but some room for individualization remains.
 

IGBT

Lifer
Jul 16, 2001
17,958
138
106
They gave me pill laxatives...two bottles of the fuggers. And now I'm told they didn't work and weren't able to complete the colonoscopy ...so I get to do this all over this time with a liquid laxative..and shite and shite all over again. This happen to anybody else??
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
They gave me pill laxatives...two bottles of the fuggers. And now I'm told they didn't work and weren't able to complete the colonoscopy ...so I get to do this all over this time with a liquid laxative..and shite and shite all over again. This happen to anybody else??
Not common, but happens.
 

IGBT

Lifer
Jul 16, 2001
17,958
138
106
Cologuard looks for changes in your DNA that could indicate the presence of colon cancer . you have to take care of health
wondering why it has a high false positive rate?? the gastrologist I went to was massively over booked with follow up testing due to false positive outcomes...
 

mike8675309

Senior member
Jul 17, 2013
507
116
116
DNA-based colorectal tests have no history of data to call them reliable. You can use it, but don't do that instead of any other screening. Make sure you are having a conversation with your doctor so that you can understand the risks of any colon screening options you have so that you can make an educated choice.
 
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TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
wondering why it has a high false positive rate?? the gastrologist I went to was massively over booked with follow up testing due to false positive outcomes...
Because Cologuard detects DNA of colonic neoplasia AND for blood. The false positives are likely positive blood that was related to something other than cancer.
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
DNA-based colorectal tests have no history of data to call them reliable. You can use it, but don't do that instead of any other screening. Make sure you are having a conversation with your doctor so that you can understand the risks of any colon screening options you have so that you can make an educated choice.

Well this is just wrong.
 

mike8675309

Senior member
Jul 17, 2013
507
116
116
Well this is just wrong.
Where is your research to back that up? Any current research I find indicates it should not be relied on as the only test.

Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives
STRENGTHS AND LIMITATIONS OF FECAL DNA TESTS
A major advantage of fecal DNA tests as compared to either FOBT or colonoscopy is the fact that they are not affected by proximal location of tumors[32,33]. Another advantage is the lack of need for purging or dietary changes.
However, the sensitivity of fecal DNA tests appears to be lower for adenomas when compared to CRC detection (Table (Table1).1). In addition, although there is evidence of reductions in CRC incidence and mortality from randomized controlled trials of fecal occult blood test (FOBT) screening[34], similar data are lacking for fecal DNA tests.
Other technical difficulties may involve the burden of large volume stool collection and shipping for the patients undergoing screening[31]. In addition, the fact that in the latest study of Imperiale et al[17] the DNA tests had over twice as many abnormal results as FIT, with a higher rate of false-positive results implies that more colonoscopies would be needed to further evaluate for CRC in the former arm. Thus, the inevitably higher number of diagnostic testing would increase the costs and risks of screening. Only with the current screening method of gFOBT, 690011 colonoscopies for false positive screening tests result in an additional estimated annual cost of £800000000[19].
Cost-effectiveness per se seems to be a major disadvantage of fecal DNA tests as both older and newer studies, particularly based on a Markov model, have concluded that fecal DNA is cost-effective only when compared with no screening, but is essentially dominated by most of the other available screening options, including FOBT and colonoscopy[36,37]. This may necessitate the limitation of number of DNA markers to render their clinical use more reasonable[38].
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
Where is your research to back that up? Any current research I find indicates it should not be relied on as the only test.

Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives
STRENGTHS AND LIMITATIONS OF FECAL DNA TESTS


Sensitivity for CRC detection was about 92%, colonoscopy is about 95%. Not dramatically different. Also note that location and stage of the CRC did not affect sensitivity in that study.

It's true that there are no RTCs of MT-sDNA testing for CRC, to say that these test "have no history of data to call them reliable" is wildly inaccurate. Keep in mind we're also talking about screening for CRC, not detection of adenomas where MT-sDNA testing falls off considerably compared to colonoscopy. The article you've cited is essentially a review of "the new test" and strong argument that it should not replace colonoscopy - a point I wholeheartedly agree with, however, as I said, suggesting that there's no data to support MT-sDNA is just wrong.

I would always recommend colonoscopy as the preferred screening modality, but Cologuard serves as an actually pretty nice option for certain patient populations.
 

mike8675309

Senior member
Jul 17, 2013
507
116
116
...suggesting that there's no data to support MT-sDNA is just wrong.
I didn't suggest there is no data to support MT-sDNA. I stated "no history of data to call them reliable" and based on both studies they call out the issue of false positives with MT-sDNA, thus they are unreliable. Do they make sense in some cases, sure and the false positive rate is generally below 20% which may mean it's worth doing this test vs a colonoscopy which has some clear risks that the MT-sDNA test does not have. The importance is to make it clear to those patients the risks so they can balance them personally.
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
I didn't suggest there is no data to support MT-sDNA. I stated "no history of data to call them reliable" and based on both studies they call out the issue of false positives with MT-sDNA, thus they are unreliable. Do they make sense in some cases, sure and the false positive rate is generally below 20% which may mean it's worth doing this test vs a colonoscopy which has some clear risks that the MT-sDNA test does not have. The importance is to make it clear to those patients the risks so they can balance them personally.

So now your definition of "unreliable" meaning that you should not use this screening test is false positive rate? Firstly, false positive rate for Cologuard is about 14% (at least in the study published in NEJM above). Well, sensitivity of PSA for prostate cancer is much lower than that of MT-sDNA and false positive rate is dramatically higher, so by your definition it's far more unreliable and should not be used as a screening test? False positive rate of mammography is somewhere around 10%, not too far from Cologuard - so we nix it as well? Pap with HPV cotesting (generally standard of care) can rise near 30% - do away with it? LDCT false positive somewhere around 15-25% - gone? Would you also agree that there is "no history of data to call [these tests] reliable?"

Obviously these numbers are fairly fluid, depending significantly on study population and testing strategy - but I think the point is clear. Your definition of unreliable is ... well, unreliable. This is not to mention that by virtue of being a screening test we desire high sensitivity and tolerate lower specificity which implies tolerance of false positives - because type II error in this context is more harmful.

Of course there is importance in making risks/benefits of screening known to patients, that is a given, but patients are largely unable to truly appreciate the nuance of clinical epidemiology. Certainly it is a physician's job to distil that as possible.

I suspect what you initially meant to say was that Cologuard shouldn't replace Colonoscopy, and I wholeheartedly agree with that, but what you actually said is simply wrong.
 

pcgeek11

Lifer
Jun 12, 2005
21,595
4,666
136
For older patients I would be careful due to thinner colon walls increases the chance of a perforation of the colon. This can be deadly.


I had a colonoscopy at 50 and no polyps or abnormal indications. I'm 67 now and I'll not do another.
 
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