The DS4 is more comfortable IMO than the Xbox controller. It seems to fit naturally in my hands and is nicely rounded off where it matters. Though the XB1 elite controller, which I have, is better than the DS4 to me. Anyhow on topic, you will be fine. The controller's triggers feel natural with their concave shape and the controller is both wider than the PS3's version was and the analog sticks are spaced further apart if you remember that or have experienced that one. The only limitation I can think of would be the battery life which may or may not affect you. For me I've never played long enough for a full charge to go to 0% during game play. Others like to thrash the controller as being unusable because the battery doesn't last through whatever insane marathon session they have going.
All in all I can use any controller from any of the consoles be it PS4, XB1, or Switch pro controller and I don't miss a beat. They are honestly all fine and work well enough that I don't have any major hangups. Though if I'm being honest the Nintendo pro controller does have the worst dpad. It's small and is prone to missfiring the direction when you are pressing it quickly left to right. You can often get an accidental up or down. Anyway that's irrelevant.