I have the Fractal Design R4, and it's an excellent case. I got the window version (it was cheaper), and it's still a quiet case (compared to my old Antec 300). I have loaded it up with 4x140mm fans (front + top) and 1x120mm fan (rear). I don't have many drives, so I took out the top hard drive rack - works out better for airflow. The case is easy to work with, and it is plenty big for cable management. Also love the integrated fan controller (3 settings - low, medium, high). Front door is solid, and I never open it except to change the fan controller.
The only problem I had (and this is truly nitpicking and really a non-issue), is that some of the pre-installed motherboard standoffs were really tight. Just use a plier to get them out.