You can use assembly/machine code within qbasic it's just that it's a more awkward method than using the other languages and also qbasic is less optimized, but there is nothing stopping you from doing it.
Qbasic would be a lot more complicated and too much work. You would need to create a low level API that your high level OS functions would need to use to access hardware and that low level API development needs someone pretty well-versed in assembly language. You are likely looking at years of development ahead of you if you go this route.
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