They also had another patient who was given a very tiny dose and they too had an aggressive immune response. Some people's immune systems are very reactive so they'll need to account for massive swelling when doing these treatments.
Can't read / watch right now, but I have a hard time believing the virus can distinguish a cancerous cell from a non-cancerous one. Of the billions of "letters" encoded in the DNA strand (which get corrupted to cause runaway reproduction), how would a virus identify a specific mutation to determine if an individual cell is cancerous before infecting / destroying it?
I wonder when we'll get nanobots that will just eat cancers alive.
I wonder when we'll get nanobots that will just eat cancers alive.
I don't think it does. I think they inject the polio directly into the tumor. Brain surgery. It spreads through the tumor from there. I think the dosage is even more important here because too much may mean it transmits through the tumor to the brain.
Also they use a special lab modified version of the virus which has fewer of the polio things. Or reduced risk of getting polio or something.
Well, then, I don't see how that's any better than just cutting the tumor out. It would have to get every single cell with cancerous DNA to be effective on terminal cancers...including the stray ones spreading through the body's systems that haven't metastasized into a tumor yet.
They also had another patient who was given a very tiny dose and they too had an aggressive immune response. Some people's immune systems are very reactive so they'll need to account for massive swelling when doing these treatments.
Well, then, I don't see how that's any better than just cutting the tumor out. It would have to get every single cell with cancerous DNA to be effective on terminal cancers...including the stray ones spreading through the body's systems that haven't metastasized into a tumor yet.
Other researchers are experimenting with cancer treatments using viruses including HIV, small pox and measles. But polio was Dr. Gromeier's choice because, as luck would have it, it seeks out and attaches to a receptor that is found on the surface of the cells that make up nearly every kind of solid tumor. It's almost as if polio had evolved for the purpose.
I did not watch the thing yet but I heard about this. It's pretty sweet.
It makes me wonder if there is a natural way to cure Cancer. Or rather, if there would have been a natural way to cure Cancer. In the evolution of things, is it possible that polio emerged as a natural counter to Cancer? Then we killed polio and so it never had a chance to evolve into a natural cure? Or something? Or something similar to what this might mean?
Legit question. It may not even make sense. I'm not a doctor, or a biologist, or an anthropologist, or a science geek.
Well, then, I don't see how that's any better than just cutting the tumor out. It would have to get every single cell with cancerous DNA to be effective on terminal cancers...including the stray ones spreading through the body's systems that haven't metastasized into a tumor yet.
A particular type of brain cancer and 50% died.
So this means....
THE POLIO VACCINE CAUSES CANCER!
/dons measles flame suit
P.S. My polio vaccine tasted like bubblegum. Would dose again.
Can someone give me the TL;DW; version?
The polio virus receptor (aka CD155) is on many many different cells, not just tumor cells. The virus they're using here should be able to enter most of them. There's little to no cancer specificity there.
Having just scanned the article, I think it works similar to how the HPV based oncolytic viruses work.
So - a normal cell has tumor suppressor genes, the two main ones being p53 and RB. They're both multifunctional, but generally act to stop cell growth or cause apoptosis (cell death) if things seem to be going wrong. There's a very long list of cancers in which either or both of these genes are mutated, including glioblastoma. link. (TP53 at the top)
When HPV infects a normal cell, it makes two genes, (among others) E6 and E7, which bind to and inactivate RB and p53. This allows (or causes) the cell to grow and makes it more difficult to kill. Rarely it can even make the cell cancerous.
Now, what happens when you make an HPV without E6 and E7? It can't grow in a normal cell (even though it can enter it) because it RB and p53 are there stop it. It's an abortive infection. But if it gets in a tumor cell it can grow due to no functional p53/RB, and eventually lyse the cell. Thus, the cancer cell is permissive to the virus, normal cells aren't. That's where the specificity is.
They remove the polio DNA from the polio cell and they edit the DNA of the polio so that it just attacks the cancer.
Before and after xrays show the cancer all over the body.
The after video shows depending on the how they edited the polio that the cancer cell will either shrivel up and die or will die by exploding.
They remove the polio DNA from the polio cell and they edit the DNA of the polio so that it just attacks the cancer.
Before and after xrays show the cancer all over the body.
The after video shows depending on the how they edited the polio that the cancer cell will either shrivel up and die or will die by exploding.
Here's What '60 Minutes' Didn't Tell You About The 'Miracle' Glioblastoma Treatment
http://www.forbes.com/sites/arlenew...you-about-the-miracle-glioblastoma-treatment/
When are they going to find a cure for the eternal pessimist?