"Treating obesity with dietary prevention and exercise is like putting sunscreen on melanoma. It's too late," Hughes told CNBC. "People who have established obesity, they will need treatments, they will need care to get out of that, and unless we wake up to that fact and understand and research what is at the heart of that problem, we're not going to have an answer."
Zafgen's compound, beloranib, is in mid-stage trials in obesity and is also in testing for a rare disease called Prader-Willi Syndrome, a genetic disorder characterized by an uncontrollable drive to eat. It works in a different way from the other three medicines, which aim to reduce appetite; "it works to really impact the way that the body handles fat," Hughes said.
He added that one of the biggest hurdles facing obesity drugs is a bias against treating obesity as a disease, something he believes needs to change.
"In general over the years, people have regarded obesity as a problem of the patient," Hughes said, "that it's their responsibility for becoming obese and it's their responsibility to become lean again, as if that works."
If you get fat enough, it actually becomes pretty difficult to exercise. You try strapping on a 150 pound fat suit and see if you can still run an 8 minute mile.
If you get fat enough, it actually becomes pretty difficult to exercise. You try strapping on a 150 pound fat suit and see if you can still run an 8 minute mile.
As someone who lost 50lbs with EC stack (first 100lbs on my own, so 150 total), I can definitely vouch for pills. It's not the "fat burning" BS of the pills, it's the brain functions telling me "ITS TIME TO EAT, STUFF SHIT DOWN YOUR THROAT! THATS NOT ENOUGH KEEP GOING ANOTHER BAG OF CHIPS" that honestly throws me off.
BS you used the shake weight.
If you get fat enough, it actually becomes pretty difficult to exercise. You try strapping on a 150 pound fat suit and see if you can still run an 8 minute mile.
Imagine a pill that fulfills your calorie intact for the whole day and makes you feel full and have no cravings.
The pills more likely work as a placebo convincing fat people that they now have the willpower to stop eating so god damn much.
If they just had willpower and forced themselves to stop overeating they could lose weight. It would eventually be enough weight for them to use their new found willpower to actually go exercise.
I need that pill. I just bring in the groceries and I'm sweating. I guess sweating is good because your losing calories but at my weight it fucking hell to lose. If your not over weight and have no clue then STFU!
I have gone without eating dinner, did it help F no!
Maybe we need a pile for big mouths.
Eating healthy is a lot like quitting smoking. You are addicted to fat, sugar, etc and when you stop your body screams for it. Willpower is not something our society values so most people simply don't have it.
Top that off with the fact that losing weight means being every so slightly hungry. That's another willpower issue.
It's a long road.
Clearly the animal called humans likes to eat, but varies on how much we like it, and how resistant to exercise we are. Modern first world conditions are such that food is unlimited, AYCE, and nobody is forced to exercise to get food.
One other effect is that the more fat you have, the more you have to eat to gain more weight. At say 150 lbs if you eat an extra cheeseburger a week you might gain a pound a month. At say 250 lbs you might need to eat an extra cheeseburger a day for the same pound a month gain. What that means is that by the time you hit 250 lbs your diet vs exercise is WAY out of balance so cutting back a cheeseburger a week you might still gain weight until you reach the weight where diet meets increased fat resisting more gains.
Seems true for many fat people, regardless of the method of losing weight, as the weight is lost the craving for food increases.
One thing is clear, a pill that worked would make somebody really really rich.
If you get fat enough, it actually becomes pretty difficult to exercise. You try strapping on a 150 pound fat suit and see if you can still run an 8 minute mile.
Oh,.. and it's not your fault,...
Packing on weight would have come before farming came into being.I read somewhere (and it kind of makes sense) that once humans were able to figure out farming, packing on weight became part of the DNA as an "insurance policy" if mother nature didn't deliver the goods as usual, (drought, massive rainfall, ect). It is a known fact that if you cut off a persons food supply the fat cells will of course empty but if the starvation continues the body will take from other areas and not destroy the empty fat cells, once again the "insurance" comes into play, those fat cells can be re-filled when food becomes plentiful again.