no it wouldn't..
if you had the PC66 stick overclocked, that is.
many PC66 sticks come with 10 nanosecond chips which means that the chips are good up to 100, so you can run them at 100mhz without worries (I had one like that).
the RAM runs as fast as the clock cycle you put it as, so if you put your brand spanking new PC133 sdram (which means a minimum of 133mhz capability), on with PC100 RAM, and ran it at 100mhz, you'd effectively only have 320 megs of PC100 SDRAM. same thing if you lower things down to 66mhz, you'd effectively have PC66 ram.