Do you need food?

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Mixolydian

Lifer
Nov 7, 2011
14,566
91
86
gilramirez.net
I think the problem with a pill would be the filling sensation.
Our bodies are used to large quantities of food (compared to a pill that is), so I'm not sure a pill is the best idea and it remains to be proven that this shake is.

Yeah, ideally the pill would be able to make you feel full as well as satisfying the body's nutritional needs.
 

Doppel

Lifer
Feb 5, 2011
13,306
3
0
Meal replacement powders have been around forever, I'm not sure why this guy is getting press. Also hospitals have liquid sustenance. He really has invented nothing.

I am fairly sure there has been at least one studying indicating that satiety relies in part on chewing, irrespective of calories. There is something innately satisfying about eating.

I'm not sure liquified fiber is as useful as solid, but that aside this will surely affect the digestive system in some way.

I imagine that even with perfect nutrition that since the body is designed around consumption of food there will be a problem following an all liquid diet long term.

EDIT: Just read jackstar's post above mine. Makes sense, and I am guessing most of us just intuitively knew this guy was smoking something.
 
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Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
Here's a rather depressing "article" where all I see is someone nay-saying with no evidence for all the criticisms. Criticisms informed by clear evidence and a display of knowledge would be so helpful in response to this kid's idea... and instead we get this junk.

http://www.businessinsider.com/rob-rhinehart-food-substitute-eating-disorder-2013-3

Historically attempts which are also "science based" have been failures. The body is designed to process, not just absorb. That's basic physiology. I can see a potential benefit for certain disease states and temporary diet management. Otherwise it's a disaster waiting to happen. The gut isn't a passive absorber but responds to food which regulates a good many things. The flora of the gut is going to be thrown off. What's going to happen to his clotting mechanism long term? "Rarely takes a poop" is a good enough reason on its own for dismissing it as an everyday alternative. He might as well say that he's found all the ingredients needed for life, tosses them in a blender and applies a spark to the result and believes life will result. After all is all there. Biology fail
 

jackstar7

Lifer
Jun 26, 2009
11,679
1,944
126
Historically attempts which are also "science based" have been failures. The body is designed to process, not just absorb. That's basic physiology. I can see a potential benefit for certain disease states and temporary diet management. Otherwise it's a disaster waiting to happen. The gut isn't a passive absorber but responds to food which regulates a good many things. The flora of the gut is going to be thrown off. What's going to happen to his clotting mechanism long term? "Rarely takes a poop" is a good enough reason on its own for dismissing it as an everyday alternative. He might as well say that he's found all the ingredients needed for life, tosses them in a blender and applies a spark to the result and believes life will result. After all is all there. Biology fail

The flipside to me is that this kid is putting himself through it and keeps getting checked out by doctors regularly. He's certainly not the first, but his goal is efficiency first and foremost and that simple idea is intriguing and worth exploring. Apparently the first group of test subjects is also having good results. He even had a good dentist visit.

I find too many people are just dismissive without solid reasoning. The pun seems too appropriate, but people just seem to have gut reactions and run with them and there's all this nay-saying without enough science/evidence to support it.
 

DrPizza

Administrator Elite Member Goat Whisperer
Mar 5, 2001
49,601
166
111
www.slatebrookfarm.com
He gets a shoulder shrug from me. Not sure what's new. I feed milk replacement powder to a lot of my baby goats. It's basically a bunch of stuff mixed together that I pay $60 for a 24 pound bag of. I mix it in warm water, and they drink it from bottles. So, he's got a human version? Big deal.
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
The flipside to me is that this kid is putting himself through it and keeps getting checked out by doctors regularly. He's certainly not the first, but his goal is efficiency first and foremost and that simple idea is intriguing and worth exploring. Apparently the first group of test subjects is also having good results. He even had a good dentist visit.

I find too many people are just dismissive without solid reasoning. The pun seems too appropriate, but people just seem to have gut reactions and run with them and there's all this nay-saying without enough science/evidence to support it.

I get what you're saying but my objections are science based. If his fecal production is minimal that means his colon is being subjected to higher levels of toxins for longer. That results in an increased chance of colon cancer. That's hard to dismiss. Short term? Sure, but I'll bet it has long term issues.
 

Mo0o

Lifer
Jul 31, 2001
24,227
3
76
Not sure why this is getting news. There are tons of patients who, for various reasons, get fed via a nastrogastric or gastric tube. They get a solution that is nutritionally dense and tends to provide the necessary caloric intake + vitamins/minerals. Common brands include Jevity, Osmolite, This science is old as dirt.

There's also pure IV nutrition
 

Mo0o

Lifer
Jul 31, 2001
24,227
3
76
I get what you're saying but my objections are science based. If his fecal production is minimal that means his colon is being subjected to higher levels of toxins for longer. That results in an increased chance of colon cancer. That's hard to dismiss. Short term? Sure, but I'll bet it has long term issues.

Do you have any data to support this?
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
Not sure why this is getting news. There are tons of patients who, for various reasons, get fed via a nastrogastric or gastric tube. They get a solution that is nutritionally dense and tends to provide the necessary caloric intake + vitamins/minerals. Common brands include Jevity, Osmolite, This science is old as dirt.

There's also pure IV nutrition

I am still confused as well, as I mentioned earlier, he's simply reinventing the wheel and it's blowing people's minds?...
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
Do you have any data to support this?

Health care is what I do. I'm sure you can do a lit search, but my knowledge on this topic goes beyond the Internet therefore I don't have links. That doesn't change what I know, but please look for yourself. Increased exposure to toxins in the colon has never proved beneficial.
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
I am still confused as well, as I mentioned earlier, he's simply reinventing the wheel and it's blowing people's minds?...

What he's doing has never been demonstrated safe over relevant time frames. All have is a data point over a short period of time. What scientific basis do I have to not be skeptical?
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
Health care is what I do. I'm sure you can do a lit search, but my knowledge on this topic goes beyond the Internet therefore I don't have links. That doesn't change what I know, but please look for yourself. Increased exposure to toxins in the colon has never proved beneficial.

Health care is what he does, too, he is a physician. Certainly we are asked to provide evidence when making a fairly bold statement of "xxx increases risk of xxx." Such a well known fact should have published data, and I believe MoOo would just like to see it, as would I. Would be a good piece of information for us to have.
 
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Murloc

Diamond Member
Jun 24, 2008
5,382
65
91
Here's a rather depressing "article" where all I see is someone nay-saying with no evidence for all the criticisms. Criticisms informed by clear evidence and a display of knowledge would be so helpful in response to this kid's idea... and instead we get this junk.

http://www.businessinsider.com/rob-rhinehart-food-substitute-eating-disorder-2013-3
the article does look bad but he has a point: this guy has no scientific background and is ignoring assimilation, interactions, degradation of food, the fact that the bowels are an organ made to get real food and if you don't shit often enough you can get cancer.
Basically he's trying to make his body do something it wasn't designed for, this is obvious and doesn't require proof.
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
Health care is what he does, too, he is a physician. Certainly we are asked to provide evidence when making a fairly bold statement of "xxx increases risk of xxx." Such a well known fact should have published data, and I believe MoOo would just like to see it, as would I. Would be a good piece of information for us to have.

If you are asking if I have proof that his procedure causes cancer of course not. The body does produced toxins which need to be eliminated. I don't think you need a link for that. He admits that he deficates little but his metabolism will not have changed in this regard. That creates a basis of concern. That's a theoretical concern but even if it proves incorrect it changes nothing. What rigorous studies have been done to prove that what he does is safe long term? It's not for us to prove him wrong but for him to use science to prove he's right.

That's how science and medicine works. Proof means something. Until then no rational provider could possibly endorse. He may be a physician but he's forgotten how the real scientific world works.
 

TheVrolok

Lifer
Dec 11, 2000
24,254
4,090
136
If you are asking if I have proof that his procedure causes cancer of course not. The body does produced toxins which need to be eliminated. I don't think you need a link for that. He admits that he deficates little but his metabolism will not have changed in this regard. That creates a basis of concern. That's a theoretical concern but even if it proves incorrect it changes nothing. What rigorous studies have been done to prove that what he does is safe long term? It's not for us to prove him wrong but for him to use science to prove he's right.

That's how science and medicine works. Proof means something. Until then no rational provider could possibly endorse. He may be a physician but he's forgotten how the real scientific world works.

So you have absolutely no evidence whatsoever that this type of diet would lead to an increased risk of colon cancer, which was MoOo's original question? Fair enough.

What toxins are produced by the body that would need to be eliminated through feces? Is there any particular reason to believe that this gentleman's bowels have stopped moving and would not be eliminating the normal things that are eliminated? Given that the bulk of human feces is undigested material and bacteria it would seem that he's having less stool because .. he's not eating much that goes undigested.

For some background, I, like MoOo, am also a physician and have also spent time doing bench research at UPenn. I'm quite familiar with medicine and science.
 

Mo0o

Lifer
Jul 31, 2001
24,227
3
76
If you are asking if I have proof that his procedure causes cancer of course not. The body does produced toxins which need to be eliminated. I don't think you need a link for that. He admits that he deficates little but his metabolism will not have changed in this regard. That creates a basis of concern. That's a theoretical concern but even if it proves incorrect it changes nothing. What rigorous studies have been done to prove that what he does is safe long term? It's not for us to prove him wrong but for him to use science to prove he's right.

That's how science and medicine works. Proof means something. Until then no rational provider could possibly endorse. He may be a physician but he's forgotten how the real scientific world works.

I agree the onus is on him to prove that what he is doing is beneficial or at least safe. But we also can't randomly speculate as to possible harms without some basis in known human physiology or existant data.

I think it's a little too simple to simply say "the body produces toxins, he is not pooping as much, thus he is at increased risk for colon cancer." Do you know specifically which "toxins" are created in the body that must be eliminated? Perhaps his diet alters the production of such toxins and his decreased bowel movements reflects decreased stool production (which is likely the case given that he is now taking in very little roughage).

I tried looking in pubmed for any data on use of tube feeds with rates of colon cancer (which is the closest thing I can think of to his situation) but havent found anything. There is some data to suggest chronic constipation is at least linked with increased incidence of colon cancer, but that data is full of caveats and likely doesnt apply in his case (since his diet is drastically different and may not really count as constipation)
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
50,879
4,266
126
I agree the onus is on him to prove that what he is doing is beneficial or at least safe. But we also can't randomly speculate as to possible harms without some basis in known human physiology or existant data.

I think it's a little too simple to simply say "the body produces toxins, he is not pooping as much, thus he is at increased risk for colon cancer." Do you know specifically which "toxins" are created in the body that must be eliminated? Perhaps his diet alters the production of such toxins and his decreased bowel movements reflects decreased stool production (which is likely the case given that he is now taking in very little roughage).

I tried looking in pubmed for any data on use of tube feeds with rates of colon cancer (which is the closest thing I can think of to his situation) but havent found anything. There is some data to suggest chronic constipation is at least linked with increased incidence of colon cancer, but that data is full of caveats and likely doesnt apply in his case (since his diet is drastically different and may not really count as constipation)

If I said or implied that cancer is a certainty then I amend that. Lets say that in other cases where toxins are in long term contact with mucosa there's been increased incidence of cancer.

The digestive system is often thought of as an absorber of nutrients and eliminator of waste. That's a very simplistic and incorrect view.

link to abstract

The GI tract is now recognized having significant impact on the immune system. That wasn't known many years ago. What are the long term changes in flora and their effects?

Remember that colorectal cancer is an example. My problem is that people are taking an engineers view of this. Add all the nutrients and voila! Biological systems have never proven that simple and will never be. Consequently I have reservations based on more than "it can't work". I think the person who is attempting to popularize this is doing a great disservice and I expect a book "How to stop eating" or some such thing along with a commercial venture to package and sell. As one who saw how DES, a "perfectly safe" medication turned out I'm not cutting this guy any slack. It's my professional imperative to be highly skeptical.
 

Mo0o

Lifer
Jul 31, 2001
24,227
3
76
If I said or implied that cancer is a certainty then I amend that. Lets say that in other cases where toxins are in long term contact with mucosa there's been increased incidence of cancer.

The digestive system is often thought of as an absorber of nutrients and eliminator of waste. That's a very simplistic and incorrect view.

link to abstract

The GI tract is now recognized having significant impact on the immune system. That wasn't known many years ago. What are the long term changes in flora and their effects?

Remember that colorectal cancer is an example. My problem is that people are taking an engineers view of this. Add all the nutrients and voila! Biological systems have never proven that simple and will never be. Consequently I have reservations based on more than "it can't work". I think the person who is attempting to popularize this is doing a great disservice and I expect a book "How to stop eating" or some such thing along with a commercial venture to package and sell. As one who saw how DES, a "perfectly safe" medication turned out I'm not cutting this guy any slack. It's my professional imperative to be highly skeptical.

Overall his "invention" likely will not amount to anything because we already have liquid meals. Theyre used very frequently in both inpatient and outpatient settings, often for many years. The long term effects for this kind of feeding in a healthy population is unstudied and obviously could not be done in a randomized, placebo-controlled way in a population that requires this for survival. But as far as I know, the biggest risks of this feeding usually comes from recurrent aspiration (usually reflective of the underlying disease mechanics) and the feeding tube itself. I have not seen any data suggesting these tube feeds are linked to increased rates of cancer or autoimmune disease.
 
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