Back in the day. Then I had some Radeon's that did weird things when OCed, in a dual monitor config. I've got a GTX680 now, and while I had OCed it for awhile I eventually turned it back to stock. Its just not necessary for the games that I play at 1080p.
Now if I had a higher resolution monitor... yes, hell yes.
Now if I had a higher resolution monitor... yes, hell yes.