Given that this was a discussion with Fox News, I would agree with Mr. Cheadle in regard to the specific instances that are likely being referenced by Fox News (e.g. Gina Carrano). However, I do think that we have an issue with cancel culture, but I don't think the issue is cancel culture itself. The problem is that people fire their metaphorical guns a bit too early and without knowing the whole story. To be clear, this isn't talking about seeing months of someone's malignant Twitter history or a video of a country music star nonchalantly dropping the n-bomb. The problem is with how there are enough holes in the existing reporting where someone should logically say "this could be bad, but I don't have enough to make an informed decision"; however, they end up filling the holes with whatever satisfies their cognitive bias. An example of this was when people latched onto the narrative that those Kentucky Christian school students were surrounding that Native American man as an act of intimidation, but that narrative was just an assumption. It turned out was wrong, but it didn't stop people from latching onto it because of the MAGA-centric nature of those teens.
One thing that makes this bad is that once it's on the Internet, it's out there. Sure, this can include bad tweets/posts that you did make, but it can also include articles/posts about someone that are arguably based upon assumption or presumed guilt. What happens when that person is found to not have done what was suspected? An example of this would be the ScreenJunkies' Andy Signore. He will admit that he did use his position of power to flirt with and make advances on fans, which is bad, but he also had sexual harassment allegations made against him. Those allegations turned out to be false, but the damage was done.
As a note, most of the disdain for her comes from the collection of tweets and posts that include topics such as anti-vax, anti-mask, etc. I'll have to look into theses tweets/posts more because I haven't personally seen them; I've only seen them mentioned as part of the story. I actually agree that her latest tweet wasn't nearly as bad as I expected based upon the narrative being pushed. That doesn't mean that I cared for its message or even thought it was accurate, but I do think most of the vitriol for her is a combination of everything.