Effective octane is much, much higher if you're comparing to race gas/etc in a forced induction application. Running ~30% more fuel results in a dramatic cooling effect, somewhat like running water/meth injection all the time.
Running 30% more fuel also results in a dramatic emptying of the fuel tank.
We know that adding 10% ethanol reduces fuel economy by 2-3%.
E15 is 50% more ethanol, so we can expect what, 4-5% worse fuel economy?
Roughly, if you get 35mpg highway, you should expect about 33mpg with E15?
I remember complaints about the blend pumps at some point in the past. If I pump 20 gallons of E85, how much E85 is left in the hose/lines for the next person?
Particularly if the next person is filling a small tank like on a motorcycle.