Is 450mm suffering from the same kind of things, or was it simply not supported by many companies because they couldn't afford it anyway?
450mm is a separate situation entirely.
The challenge with 450mm is no different than the challenge of every wafer size change that came before it - basically that you can't do anything until you have everything.
What that means is you have a real catch-22 situation with wafer transitions if you are the tool vendor. Be the first to produce a 450mm etch tool and you still can't sell them unless someone else is also selling a 450mm wet cleans tool, or 450mm litho tool, or 450mm deposition tool, etc. etc.
But the deposition company doesn't want to be first with a 450mm deposition tool, because no one will buy it until that 450mm etch tool is available, and so on.
So the challenge is really just one of coordinating roadmaps across tool suppliers (no small feat as each are beholden to different masters when it comes to R&D investments, margins, growth, etc.), combined with coordinating tool availability roadmaps with the customer's roadmaps in terms of when they might even be thinking of building another $14-20B fab.
But there aren't any what I would consider to be "technical barriers" to scaling all the existing wafer handling and process technologies that exist today at 300mm to a 450mm dimensionality. Unlike EUV which basically had no predecessor at any dimension, let alone 300mm or 450mm.
The barrier for EUV is nearly entirely technical, getting enough photons generated in a sustainable (high duty-cycle) manner so as to have throughput/meter^2 be high enough as to become commercially viable. Pour billions of dollars into that basic research all you like, isn't going to make the scientists have their brilliant breakthroughs any faster.
(analogies to fusion energy are directly applicable here, although EUV stands a better chance of becoming commercially viable at least a century sooner)
In contrast to 450mm where the only thing keeping it from being a reality today is that no one is interested in committing $20B today to build the first 450mm fab. But as soon as some company makes that decision and commitment, the tools will be available shortly thereafter. The same thing happened with 300mm, no one wanted to be first but once someone pulled the trigger then everyone scrambled to be next in line.