Well, one thing I got of the exchange is that I spent some time thinking about empathy.
Because they're human shaped, I pretty much treat the NPCs in a game like Fallout 3 as humans. They aren't really humans, obviously, they're little snippets of code and animations, but I pretend their humans. It's the "role playing" part of RPG.
Dredd doesn't. In a sense, he's right that they're not real, and he blames the game for not convincing them that they're real. I see it at least as a partly a failure on his part to try to suspend disbelief. After all, they do have a lot of surface detail. They look like people (as much as CPRG people look like people), they have daily routines, they have some conversational bits, some more than others.
The reason I've never blown up Megaton, and never will, is that I'm willing to go along with the game and project myself into the situation - would I really kill a town full of people just to make a few caps? No. I'll defend myself, but murder is not something I do, let alone mass murder.
I have a high body count, of course, but I'm only so casual about killing raiders because I know what they'll do if I don't. That's part of the fiction, if I were really out in the wasteland, assuming that raiders will kill and eat me if they can is only being realistic.