Desktop/Work:
Final Cut Pro (still using FCS 6, at work and home)
DVD Studio Pro
Motion
Compressor
Taply (great little tool for quickly previewing audio media- been using since long before QL and still use it daily)
MediaCalculator (calc for timecode, film footage, drive record space, etc.)
Photoshop PS3 (I'm not a big fan of 4)
Toon Boom Storyboard Pro (now the animation indy standard)
Autodesk Sketchbook Pro (drawing tool)
Flash
Anime Studio
Pages
Final Draft
MS Office 2008
Dreamweaver
Free Ruler (ah the convenience sometimes of just being able to measure the screen)
Toast
Virtual Box (a fantastic free alternative to VMware Fusion and/or Parallels)
MacPar Deluxe (file archiving tool)
Egg-Time Counter (time management)
LameSecure (tool to lock directories)
BlueHarvest (invaluable for keeping @**&ing ._resource fork droppings off servers)
Live Mesh (for sharing projects/files across multiple users/machines/homes/offices- replaced Drop Box for me, which I've since dropped like a hot potato)
Adium
Cyberduck
Fugu (SFTP, SCP, SSH)
uTorrent
Home Theater/Entertainment:
Plex (Media center, based on XBMC only much better. )
XBMC (media center)
NicePlayer (awesome alternative to DVDPlayer, borderless interface=priceless)
Hulu Desktop (simply awesome)
Boxee (also awesome)
eyeTV
Air Mouse (makes an iPhone/iPod Touch into a gesture remote)
Remote Buddy (makes Wiimote, PS3 BD etc. into remote)
Google Earth
MAME (arcade game emulator)
SixtyForce (N64 emulator)
LastFM app
iTunes
VLC (when all else fails for odd media files)