Freespace 2
Hostile Waters (Am I the only person that heard of this game?)
C&C Renegade
Dune 2 (Dune 2000 was an abomination and Emperor went off on a strange tangent for me)
Homeworld 2
Mechwarrior 5 (MWO is very good but it's Online MP only. We need some Single Player MW/BT game)
Freelancer (Was okay, plot was short and kinda crap but it was a solid game in the genre overall)
Defense Grid: The Awakening (DLC's don't count)
Sol Survivor (Solid TD game, not quite to the standard of Defense Grid but threw in some interesting elements)
Aquanox 2 (looked beautiful, played really well but never became a huge hit)
DarkStar One (Like Freelancer only not as good but did have a nice ship customisation mechanic which I enjoyed)
Endless Space (Great indie 4X. Really deserves a sequel)
Fallout 2 (Fallout 3 is good and worthy of the FO name but I'd like to see a new FO game set with the same mechanics/viewpoint/gameplay as FO1 and FO2)
Gal Civ 2 (Space 4X deserves a new one)
Nexus: The Jupiter Incident (Too complex for most gamers but was fantastically tactical with capital ships. Kickstarter for Nexus 2 failed )