Originally posted by: illustri
Originally posted by: CycloWizard
Originally posted by: illustri
- study is published in human genetics, jan 12
- genetic studies have been done from fewer samples
- news site may have agenda but researcher did not
- research before you scream baseless accusations
1. I didn't scream anything - I simply made observations.
2. I have no stake in which side the hammer falls on in this debate, as I don't see how a genetic predisposition forms the basis of rights any more than a selected state of mind/sexual preference.
3. I'm not seeing the article in Human Genetics/J. of Human Genetics. Have a page number/title?
Edit: Not in Human Genetics.
Behavior Genetics
Publisher: Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
ISSN: 0001-8244 (Paper) 1573-3297 (Online)
you're citing a
different study by the same researcher on a
differentcandidate gene which incidentally was concluded to have no influence on male sexual orientation
abstract of the paper which was cited by the article
Human Genetics
2005 Jan 12; [Epub ahead of print]
Abstract
A genomewide scan of male sexual orientation
Brian S. Mustanski1, 2 , Michael G. DuPree1, 3, Caroline M. Nievergelt4, Sven Bocklandt1, 5, Nicholas J. Schork4 and Dean H. Hamer1
(1) Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA
(2) Institute for Juvenile Research Department of Psychiatry, University of Illinois at Chicago (M/C 747), 1747 W. Roosevelt Road, Chicago, IL 60608, USA
(3) Department of Anthropology, Pennsylvania State University, University Park, Pa., USA
(4) Department of Psychiatry, University of California, San Diego, Calif., USA
(5) Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA
Received: 16 September 2004 Accepted: 30 November 2004 Published online: 12 January 2005
Abstract This is the first report of a full genome scan of sexual orientation in men. A sample of 456 individuals from 146 families with two or more gay brothers was genotyped with 403 microsatellite markers at 10-cM intervals. Given that previously reported evidence of maternal loading of transmission of sexual orientation could indicate epigenetic factors acting on autosomal genes, maximum likelihood estimations (mlod) scores were calculated separated for maternal, paternal, and combined transmission. The highest mlod score was 3.45 at a position near D7S798 in 7q36 with approximately equivalent maternal and paternal contributions. The second highest mlod score of 1.96 was located near D8S505 in 8p12, again with equal maternal and paternal contributions. A maternal origin effect was found near marker D10S217 in 10q26, with a mlod score of 1.81 for maternal meioses and no paternal contribution. We did not find linkage to Xq28 in the full sample, but given the previously reported evidence of linkage in this region, we conducted supplemental analyses to clarify these findings. First, we re-analyzed our previously reported data and found a mlod of 6.47. We then re-analyzed our current data, after limiting the sample to those families previously reported, and found a mlod of 1.99. These Xq28 findings are discussed in detail. The results of this first genome screen for normal variation in the behavioral trait of sexual orientation in males should encourage efforts to replicate these findings in new samples with denser linkage maps in the suggested regions.
Brian S. Mustanski and Michael G. DuPree contributed equally to this work.