Had the TRI-X as single card and in CF. Now have the Lightning (all 290x). Both are great cards. That said, the Lightning is much nicer in build quality, performance and acoustics. Even at full load that thing is inaudible and that is my opinion compared to a single TRI-X. I'll have to agree with lavaheadache, this cooler is incredible. The only thing I would consider is size. The TRI-X is a 2-slot card (not over) whereas the Lightning is 2.5-slot card. Haven't tried it in CF (though I might soon, I can get another TRI-X for real cheap), but there won't be too much space between them.
Also, I think the lottery will be better with it as those are MSI's top cards where Sapphire has the Vapor-X. And as mentioned before, the warranty is better with MSI (and a year longer).
About the 295x2, I'd get that if you want to go TriFire. IIRC, it is faster than stock 290x's as it has a slightly higher core clocks (1018 MHz) than the stock 290x's, but both the cards you are considering have higher clocks.
Edit: forgot to mention, the only way I can think of that the Lightning had worst acoustics is because the original FW had an issue that prevented creating a profile and controlling the fans separately. That was fixed and a new FW is available that allows controlling the middle fan (GPU) and the other two (rest of card) separately and create a fan curve.