I haven't personally, but my grandmother has. She works graveyard shift at the local hospital. She stopped at the local safeway to get something to eat before going to work one night, and she noticed a guy waking out from the building towards her. The parking lot was pretty much empty at 10:30 at night. Keep in mind this is a small town with less than 9,000 people. Anyways, he reached into his pocket as he was walking up and told her to drop her purse onto the ground. She told him to back off, and when he got to within about 20 feet or so, she pulled out a Beretta 9000S .40S&W from her jacket pocket and fired once, hitting him in the chest. He lived.
He is now doing time at Snake River Correctional Institute the last I heard.