Check out downtown Hendersonville and Asheville. They're just across the NC border. Charming little historic down towns. Ashville is pretty famous for it's food scene, especially small/micro breweries. Asheville is considered by many to be the San Francisco of the East coast (although waay smaller). Artists communities, music, trendy stores and all kinds of restaurants for it's size.
Check out nearby mountains (state and national parks), waterfalls and hiking tails.
Be easier to make recommendations if you told us what you were interested in and how far you're willing to drive to see other places/things.
Also, it be cold here at that time.
Fern