It would be quite difficult. Decades of federal assistance and the place is still a shithole, the schools are shit (my high school was something like 307th of 325 in terms of quality in the state with over half the students getting a free lunch), and meth and hopelessness is a huge problem.
The only thing that's going to improve their lives is economic growth. Trump promised this to them via protectionism (which is counter-productive) but these people are desperate for anything.
Another thing that can be done is to completely reform eduction to provide high schoolers with real skills. I was part of a pilot program at the high school to teach kids vocational skills (mine was CCNA training, but they had programs for mechanics, welders, etc). I can't find any solid statistics on outcomes, but it served me well. But it also requires thinking about high school as a place to get practical skills as opposed to a training ground for college (that most people in that town couldn't afford without going into massive amounts of debt anyway).
Trust me, there was no lack of knowledge in that town about how to get free money. It just wasn't doing much to improve outcomes.
I'm not questioning the motives of dems (and I don't think most people in this town does). I'm a libertarian and I caucused for fucking Bernie Sanders (because I think even though he's wrong on a lot of policies, his heart is in the right place). I'd prefer him to the face of the establishment or a bunch of religious hypocritical zealots. The problem with these policies though is not necessarily intent but the outcome. Have the decades of government handouts improved my home town? People there don't think so, so these poor working-class (with a high proportion of welfare recipients) voted for Trump. They just don't trust the government to help them. They need a way out, not generations of government dependents.
Yes, I know, this is still a lot of fluff. This is also just my first-hand account. I don't know the solution, but what we've been doing so far hasn't been working so well for these folks.