We have zero verified information about Vega's performance. Can't recommend it now for that reason, though you may wish to wait just to see where the chips fall.
multi-GPU miscellany:
multi GPU AFR rendering is a crapshoot for support. Both nV and AMD. If your game works well with it, great. If it doesn't, you're SOL.
Max SLI support is 2 cards for gaming.
Crossfire can support up to 3 or 4 cards depending on motherboard. Scaling is generally better vs SLI.
As for CPUs... quad core would bottleneck 2x 1080 Ti. You already have games like Ashes of the Singularity that gimp details on anything with fewer than 6 cores regardless of user settings, and newer games are scaling past four cores. Can't recommend a quad core unless you're on a budget, and maybe not even then - a hex core Ryzen is competitive with an Intel quad core in price and performance.
In short, I would recommend a hex core at minimum, either Intel's HEDT X99 platform or AMD's Ryzen X370 platform, IMO. Ryzen has the edge in bang for the buck though Intel has the overall performance crown. Though in GPU-bound situations that difference wouldn't really be noticeable (unless your CPU can't feed your GPUs fast enough, e.g. as mentioned with quad cores in some games).
Unknowns at this point (2H 2017 through 1H 2018):
Skylake-X - speculation is that it will combine high IPC and clock speed of 7700K into more cores, but some of that speculation is as wild as the Ryzen 5GHz hype trainers. I doubt it will turn out as good as some hope. If by some silicon miracle it does, it'll be $2K+ for the top processor, easily.
Ryzen HEDT platform aka "X399" - 12c/24t and 16c/32t workstation processors with 40+ PCI-e lanes, more comparable to Intel's HEDT platform. Unknown clocks and performance.
Ryzen 2 - next version of Ryzen processors, will likely see clock speed and IPC improvements. How much is anyone's guess.
The fact that AMD is even an option now is an improvement. My last five CPUs were all Intel... Intel C2D, Intel C2Q, Intel i5-2500K, Intel i5-3570K, Intel i7-6700K. Wouldn't have (and didn't) consider any AMD CPUs pre-Ryzen to be an option for gaming, ever.