Depends on how much it was.
First, I'd sock enough into multiple accounts to the FDIC insured limit for each. Enough to ensure I could live comfortably forever if I blew through all of my money.
Second, I'd have my general living fund to cover my anticipated required expenses until I died.
Third, I'd give enough money to all of my relatives to retire, or at least pay off a bunch of their shit, depending on how much I made.
Fourth, I'd marry a hot chick and get an ironclad pre-nup
Fifth, hookers and blow, with or without my new hot wife included.
Sixth, hire a bunch of programmers, engineers, healthcare workers, and farmers dedicated to the creation and implementation of technology to increase or ensure an acceptable quality of life in the US.
Seventh, buy politicians to reform welfare to workfare.
I would give nothing to charity unless the benefits of the donation saved me an equal or greater amount in taxes. If I did give anything to charity, it would be a charity I established, or something I deemed for the benefit solely of Americans. Because I'm not some dickhead that ignores the problems we have in this country and gives all of their extraneous income to some worthless shithole like Haiti.