Also count me into the "You're very very dead" camp.
To those who say that the sand will pass right through and leave only a grain-sized hole:
It's moving incredibly fast. It's going to want the particles of your body which are in its way to move out of the way with similar expedience. Those particles in turn will kindly ask that their neighboring particles do the same. Result: Same as what happens when you fire a tiny projectile, such as a rifle bullet, at high speed into a fleshy target. You get a hole that's much larger than the projectile.
Surely this has been done before, but what the hell...
Momentum is simply mass * velocity.
Let's go with 0.5 milligrams.
And we'll say it's moving damn fast, 299,000,000 m/s, somewhere around 99.67% c. That's still 149.500 m-kg/s
Wikipedia gives 1000m/s as the velocity of a rifle bullet, around what an M-16 could do, also according to Wikipedia.
Working backwards, that'd work out to be the equivalent of a bullet with a mass of 0.1495kg. M-16's bullet mass: less than 5 grams. So instead of being shot with a 5 gram bullet, you're being shot with a 149.5 gram bullet.
Or switch it up - a 5 gram bullet at 29,900 m/s (~98,000fps).
Either way, you're quite dead.
That's just going by momentum though. An analysis of energy transfer would likely be more accurate. In that case, we'd need to figure out if it were elastic, inelastic, or partly inelastic, should the sandgrain just punch right through and leave a gaping hole in its wake.
So let's go with good old e = mc² for the hell of it, and the half-milligram grain of sand.
44,937,758,936.8 joules.
Wikipedia gives 1MT of TNT as 4.184 * 10^9 joules.
So that sand grain would be packing 10.8MT of energy.
Or just fall back to 0.5mv², for a kinetic energy figure of 22,468,879,468.4 joules - 5.2MT.
Let's say 0.001% of that energy is transferred to you. That's still well over 2 megajoules. Result: you pretty much just blow up.