About a year ago I moved from DFW to State College, which is right smack-dab in the middle of the state of Pennsylvania.
A few things:
1) They love taxes here.
2) The state government is incompetent as hell.
3) The alcohol laws are beyond screwed up.
4) They like to bitch about the humidity, but if you came from Texas then it's no big deal for you - remember up here if the temperature pushes 90º they start to whine.
5) The highway system is absolutely horrible, possibly the worst of any state (Louisiana is pretty close though). Somewhat ironic since they have the oldest highway and they love taxes, but they don't bother to build a decent highway infrastructure - go figure.
6) Here is an upside: It is rather scenic.
7) The food blows. There may be some knuckleheads who think there is good food in Philly (who knows, maybe but I didn't find it) but the food blows - especially if you are coming from California/Texas. I checked out Pat's King of Steaks (or something like that) which is one of the self proclaimed original Philly cheesesteak joints, and they sort of blew. I think I have had better cheesesteaks at freaking Quiznos.
8) Produce is expensive - here it can cost as much as $3 for one avocado and back home in Texas I can buy 3 for $1.
9) Another upside: There are tons of other interesting cities that are relative close by (and especially after living in Texas and California everything will seem to be rather "close") such as Washington DC, NYC, Pittsburgh, Baltimore, Philadelphia, Buffalo, Toronto, etcetera.
10) The highway system really, really blows.
Good luck with Harrisburg! There is a decent brewery in town, I think called Troegs. That Yuengling Lager that others have mentioned is an okay beer - not great (they may think so) but it is far from bad either; a good stand-by when at the bar. I do drink it often - it is like the Pennsylvania version of Shiner Bock. There are some decent microbrews in this part of the country; again though Pennsylvania liquor laws are screwed up beyond belief.