Yup, whenever I could I'd buy International instead of paying more for the regular version. Like newb111 said they are usually black and white with cheaper paper. Never had a problem with them, though.
They don't take them back at the bookstore so you can't resell them, which wasn't a big deal for me at least since the bookstore gives you jack for selling back books. There were times though when I couldn't get an Int'l edition or it was about the same as a regular edition, so I'd get the regular edition (still way cheaper than getting it from the bookstore), then sell that back, haha.