Is alzheimers a broad generalization?

Anarchist420

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Feb 13, 2010
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I was thinking so. For example, my mom's mom, INTP, was dx'd with alzheimers as was my dad's mom, but my mom's mom had no heart problems and had symptoms like I believe my abilify has given me auditory processing latency, Worry problems, abstract thinking issues, closed angle glaucoma, and reducing precision in communication. I worry that my dad will sooner succumb to vascular dementia; he is an INFJ, so he won't act on the advice of others which is fine. His inferior extraverted sensing function gets very annoying, at least to me and my mom.

Dr. Fly is an ENFP and ENTPs with type O blood shouldn't have strong OCD. The abilify may even make my hair darker and more wirey. My beard is red off of it; but it is blackish now.

I have learned to teach my brain how to override it to a degree, but i need to get off of it be productive.

Auditory processing takes place in the frontal cortex and maybe the temporal lobe so I guess the abilify gives me something like temporary fronto temporal dementia.

I will be getting neurofeedback; it is newer and a lot less invasive. It goes directly to the brain rather than through the blood stream.

Also, the clinicians that do it are smarter and sweeter than those working for the pharmaceutical industry; the former get by on a lot less statism (e.g., big pharma uses taxes, patents, DEA, FDA, and more trade regs). They waste YOUR money for the pharmaceutical industry has no money of its own. Their current patents should be transferred and any new ones they get should be reduced to 5 years.

Sorry for the digression.
Your thoughts please. Thanks for reading: )

Btw I am using my mom's iPad.

EDIT 1: no my beard isn't red regardless of whether i am on abilify; it was somewhat red when i first had a beard, but that changed about 6 years ago. so now i look like an arab or like one early Neo-Republican Party monsters.

EDIT 2: i don't know what mom's mom's mbti type was.
 
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SlitheryDee

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Feb 2, 2005
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i think Alzheimer's is a specific disease within the more generalized category of dementia. It may have become the "Kleenex" of dementia in that laypeople will often call any kind of dementia Alzheimer's though.
 
Nov 26, 2005
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There has been a big break through in Alzheimers research. 3d modeling confirms that the plaque is the culprit, iirc
 
Dec 10, 2005
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i think Alzheimer's is a specific disease within the more generalized category of dementia. It may have become the "Kleenex" of dementia in that laypeople will often call any kind of dementia Alzheimer's though.

Alzheimer's is a specific type of dementia, typically associated with the appearance of plaques formed of amyloid-beta protein and tau protein tangles. There are other types of dementia that may also be amyloid-protein related (there are a bunch of proteins which can form amyloid structures, like alpha-synuclein, which is believed to be the root cause of Parkinson's disease, that would not be Alzheimer's).

There has been a big break through in Alzheimers research. 3d modeling confirms that the plaque is the culprit, iirc

Plaques are a characteristic feature of patients with advanced Alzheimer's, but the current thinking is that they are not the primary culprit of the disease. In the amyloid cascade hypothesis (which is the current hypothesis behind how the disease progresses at a molecular level), amyloid beta is cleaved by a protease from amyloid precursor protein, releasing amyloid beta monomer proteins into the cell. These monomers can come together and form toxic oligomers, which can diffuse and interact with cellular targets (causing cell disregulation and cell death). Eventually, they aggregate enough to form insoluble fibrils which make up the plaques. These days, it's believed that the soluble oligomers are actually the most toxic species in Alzheimer's disease.
 
Nov 26, 2005
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Plaques are a characteristic feature of patients with advanced Alzheimer's, but the current thinking is that they are not the primary culprit of the disease. In the amyloid cascade hypothesis (which is the current hypothesis behind how the disease progresses at a molecular level), amyloid beta is cleaved by a protease from amyloid precursor protein, releasing amyloid beta monomer proteins into the cell. These monomers can come together and form toxic oligomers, which can diffuse and interact with cellular targets (causing cell disregulation and cell death). Eventually, they aggregate enough to form insoluble fibrils which make up the plaques. These days, it's believed that the soluble oligomers are actually the most toxic species in Alzheimer's disease.

was that the pbs article?
 
Dec 10, 2005
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was that the pbs article?

What PBS article? That's just my knowledge of the status of the disease in the literature, at least in regards to the molecular basis. Earlier in my PhD (which is almost done), I had been doing some experiments and research into trying to study some of these types of systems at a molecular level, so I had become moderately familiar with a lot of the research in this area. Though, these days, I'm not working on this system anymore.
 

OverVolt

Lifer
Aug 31, 2002
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Hello A420 good to hear you are doing okay.

I think drugs could potentially play a role in Alzheimer's symptoms but even without drugs people would still have Alzheimer's due to old age.

Its due to the body's inability to sweep beta amyloid proteins from the brain, IMO.
 

amicold

Platinum Member
Feb 7, 2005
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WOW. whenever i look back at what i wrote i really come to realize how stupid i am; it makes me wish that some powerful bar bitch you ates were over the counter.

Barbies are real tasty. Anything that acts on gaba is more than likely bad news though.
 

Hayabusa Rider

Admin Emeritus & Elite Member
Jan 26, 2000
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Dude's fucking nuts. /thread

Well the question is valid though. The elderly will eventually lose some functioning however there are degrees and different causes. What some people call Alzheimers I refer to "old timers" disease. If someone suffers a series of small strokes for example there can be problems but it's not Alzheimer's which is sometimes used as a catch all phrase by the ill informed.
 

TheVrolok

Lifer
Dec 11, 2000
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Well the question is valid though. The elderly will eventually lose some functioning however there are degrees and different causes. What some people call Alzheimers I refer to "old timers" disease. If someone suffers a series of small strokes for example there can be problems but it's not Alzheimer's which is sometimes used as a catch all phrase by the ill informed.
I think the answer to the original question is no. Certainly it's used colloquially as a catch all, but so are many medical conditions. Alzheimer's is a specific diagnosis (although certainly there's a lot more to learn going forward). In the end, I think he just mildly necro'd his own thread for more attention/psych reasons.
 

Anarchist420

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Well the question is valid though.
thank you
The elderly will eventually lose some functioning however there are degrees and different causes.
+1. Although some elderly people don't lose any mental functioning at all; most do, but some don't. It's kind of weird how my grandmother's still-living younger brother (he's about 3-4 years older now than my grandmother was when she died) is very sharp mentally; he does not seem to me to be 100%, but i'm pretty sure he won't live to develop enough dementia to be dx'd with AD.

My grandfather's younger sister is now several years older than the former was when he died and everyone agrees that she hasn't declined in mental function at all; however, she had a few strokes IIRC.

My grandfather had a stroke when he was like 25 and was probably born with a tic disorder of some kind as well as manic-depression (one minute he'd be crying like a new born and then all of a sudden he'd start talking about burning a hole in the chair), but he was diagnosed with alzheimer's as well shortly before he died. he was probably just playing dumb though. he frequently had nightmares as well as good dreams where he'd talk and laugh as he was trying to sleep or wake up

as for my dad's mother, she was dx'd with alzheimer's but it's very clear that she had vascular dementia instead; i think my dad does too given how obese he is (he is the same height as i am and he weighs 25-30 pounds more) and that some days his head throbs and you can see veins. he's never done well with much disorder; he always liked a lot of uniformity quite unlike his older brothers (one of whom is dead) and his late father. he's so adorable and retarded. please feel sorry for him just like i feel sorry for cute goofy little dr. paul.

i apologize in advance if there was any of that i wasn't supposed to post here
 
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DCal430

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Feb 12, 2011
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The issue with Alzheimer's is there is now to test for it when the person is actually alive. Alzheimer's is always diagnosed by exclusion. When a person presents with dementia, there is specific known causes of dementia, most of which can be tested for or excluded directly, Alzheimer's can't. Once all causes that can be determined directly are eliminated, what you have left is likely Alzheimer's.

Because of how it is diagnosed there is a strong likelihood that a some of people diagnosed with Alzheimer's, actually don't have it.
 

Anarchist420

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Because of how it is diagnosed there is a strong likelihood that a some of people diagnosed with Alzheimer's, actually don't have it.
Same goes for other diagnoses as well. I mean, most psychiatrists I have been to don't believe that I'm schizophrenic (or schizo-affective)... yet two doctors (the one who referred me to the VB psychiatric and then the one in VB Psychiatric who diagnosed me with it) said I was. In '94 the in-patient childhood psychiatrist said I had tourette's yet a neurologist who saw me during that first psychiatric in-patient stay said there was no way i could have Tourette's; and the childhood outpatient psychiatrist who i had been seeing 2 years before then through most '95 agreed with the neurologist.

Personally, I believe conventional medicine is mostly BS. I honestly can't discern whether psychiatrists and the psychotropic drug engineers/researchers and marketers are idiots who actually believe what they tell everyone else or if they're lying trying to make above-market profits; i'd guess the former given how much aid they've required to make their living.

And while I am demented and even retarded, it should be left at that as psychiatrists sure haven't made me happy nor have they have even lead to me being happy. It's also unjust that I was never put in juvie for beating people up when i was a kid. but no one should be forced onto drugs unless they actually forced someone else onto drugs.

repeal of licensure and no prescriptions, far less bullshit in the world... that's the way it should be and hopefully the way it will be one day.
 
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