I used to not have memory issues but now I do. And then the Restart add-on I was using stopped working, so now I use a different one but it doesn't retain the placement of the windows like it used to (I don't think its the Restart add-on, I think Firefox itself stopped doing that as I've had it crash a couple of times and when doing the restore session it won't put things back like it was).
AdBlock works way better on FF than it does on Chrome, although Chrome has gotten better, it still isn't as good in my experience. I also really fucking hate how Chrome sometimes the middle mouse to open a link in a new tab doesn't work so you have to right click it and tell it to open it in a new tab.
Looking at the overhaul to the UI that's apparently coming, I'm mixed. On the one hand it took a while to get the new interface how I wanted it when they made the changes back with 4 or whenever that was, but I don't think I'll be impacted by the change too much as its already mostly how I have things setup. Except for tabs on top, I'm not a big fan of that.
Chrome is usable but I don't like it all that much, and it screws up for me sometimes too.